neonatal purpura fulminans
نویسندگان
چکیده
neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. it manifests as dic and extensive subcutaneous thrombosis. the condition is often fatal unless there is prompt diagnosis, and judicious therapy. the most important causes of this condition are infections and congenital deficiency of anticoagulant proteins c and s.in the case of pc (protein c) deficiency,the management includes an acute phase of replacement therapy with fresh frozen plasma (ffp) or protein c concentrate and a maintenance therapy that includes anticoagulation with warfarin or low molecular weight heparin. here we report a case of neonatal purpura fulminans due to suspected protein c deficiency.
منابع مشابه
Neonatal Purpura Fulminans
Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (p...
متن کاملDiagnosis and management of neonatal purpura fulminans.
Neonatal purpura fulminans is a rare, life-threatening condition, caused by congenital or acquired deficiencies of protein C or S. The condition is often fatal unless there is early recognition of the clinical symptoms, prompt diagnosis, and judicious replacement therapy is initiated. The clinical presentation is that of acute disseminated intravascular coagulation and hemorrhagic skin necrosis...
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Purpura Fulminans is an unusual condition, characterized by rapid progression, high systemic toxicity and great mortality. The clinical history of a girl aged 3 years and 6 months is presented. She was hospitalized in an Infectious Diseases Unit, from February 6 to March 3, 1981. Her illness began two days prior to admission, with fever, cpistaxis, moderate postration, violet -coloured lesions ...
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Neonatal purpura fulminans is a life threatening clinical entity characterized by extensive subcutaneous thrombosis and disseminated intravascular coagulation usually manifesting shortly after birth. We report an autosomal recessive form of the disease in a neonate who was diagnosed with compound heterozygosity for mutations in his protein C gene as the molecular basis of his disorder.
متن کاملPurpura Fulminans following Thermal Injury
Purpura fulminans is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin, which is an unusual cutaneous manifestation of disseminated intravascular coagulation. It often occurs in small children and babies due to infection and/or sepsis, rarely in adults in clinic. We report the first case of deadly purpura fulminans following thermal injury in a 64-year-old Chine...
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عنوان ژورنال:
iranian journal of neonatologyجلد ۵، شماره ۱، صفحات ۳۴-۳۷
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